If you're not being helped enough by tumor necrosis factor inhibitors (TNFis, also known as anti-TNFs), and you and your doctor decide to make a change, consider some of the potential benefits and risks of switching to Rituxan® (rituximab) in combination with methotrexate:

  • Up to 6 months of relief: Rituxan is a rheumatoid arthritis (RA) treatment that can provide up to 6 months of symptom improvement from 1 course of treatment (2 infusions given 2 weeks apart; the first infusion usually lasts 4 to 6 hours. Infusions after your first may take slightly less time, but will still last several hours). In fact, a study showed that at 6 months, 51% of the people taking Rituxan (plus methotrexate) experienced RA symptom improvement (called an ACR20 response), as opposed to 18% of people taking methotrexate alone
  • A study also showed that, of the people who saw improvement from their first course of Rituxan (plus methotrexate) and then went on to receive a second course, 54% saw an additional 6 months of improvement (as opposed to 45% of people who received methotrexate alone)
  • Rituxan dosing schedule: Rituxan is typically given every 6 months, or based on your doctor's evaluation of your symptoms (but no sooner than every 4 months). View the dosing chart
  • Helps slow the progression of joint damage: In a study, Rituxan with methotrexate was proven to slow joint damage for many patients after 1 year of treatment compared to methotrexate alone

Talk to your doctor about the results others have experienced with Rituxan, and discuss whether it may be right for you.

What are the possible side effects of Rituxan?

Rituxan can cause serious side effects, including:

  • Tumor Lysis Syndrome (TLS): TLS is caused by the fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment or an abnormal heart rhythm
  • Serious Infections: Serious infections can happen during and after treatment with Rituxan and can lead to death. Rituxan can increase your risk of getting infections and can lower the ability of your immune system to fight infections. People with serious infections should not receive Rituxan
  • Heart Problems: Rituxan may cause chest pain, irregular heartbeats, and heart attack. Your healthcare provider may monitor your heart during and after treatment with Rituxan if you have symptoms of heart problems or have a history of heart problems
  • Kidney Problems: especially if you are receiving Rituxan for non–Hodgkin’s lymphoma (NHL). Rituxan can cause severe kidney problems that lead to death. Your healthcare provider should do blood tests to check how well your kidneys are working.
  • Stomach and Serious Bowel Problems That Can Sometimes Lead to Death: Tell your healthcare provider right away if you have any stomach-area pain during treatment with Rituxan

Please see the Important Side Effect Information page and the Rituxan Prescribing Information and Medication Guide for additional Important Side Effect Information, including Most Serious Side Effects.


Hear her experience taking Rituxan.





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